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Condition (MeSH)

Spondylarthritis

ClinicalTrials.gov lists 1,256 trials for Spondylarthritis or a narrower condition beneath it. Novartis Pharmaceuticals has the most among industry and government lead sponsors, with 47.

MeSH D025241 Musculoskeletal Diseases C05
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Phase 1 Phase 1 46 Phase 1/2 Phase 1/2 9 Phase 2 Phase 2 108 Phase 2/3 Phase 2/3 15 Phase 3 Phase 3 191 Phase 4 Phase 4 132 Not applicable Not applicable 266 Observational Observational 487 Phase 1 Phase 1 46 Phase 1/2 Phase 1/2 9 Phase 2 Phase 2 108 Phase 2/3 Phase 2/3 15 Phase 3 Phase 3 191 Phase 4 Phase 4 132 Not applicable Not applicable 266 Observational Observational 487

Trials per phase (log scale)

1 more section with rows

195 of the 1,256 trials are tagged with Spondylarthritis itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Spondylarthritis trials start? (35)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 93

1991: 1 trials (Observational 1) 1993: 1 trials (Not applicable 1) 1994: 1 trials (Observational 1) 1995: 3 trials (Observational 2, Phase 2 1) 1996: 1 trials (Phase 2 1) 1997: 1 trials (Not applicable 1) 1998: 2 trials (Observational 1, Not applicable 1) 1999: 2 trials (Observational 1, Phase 2 1) 2000: 2 trials (Observational 1, Phase 3 1) 2001: 2 trials (Observational 1, Phase 3 1) 2002: 13 trials (Observational 2, Phase 4 1, Phase 3 4, Phase 2/3 2, Phase 2 3, Phase 1 1) 2003: 13 trials (Observational 5, Phase 3 5, Phase 2 3) 2004: 18 trials (Observational 9, Phase 4 4, Phase 3 3, Phase 2 1, Phase 1 1) 2005: 21 trials (Observational 5, Not applicable 1, Phase 4 6, Phase 3 4, Phase 2/3 1, Phase 2 3, Phase 1/2 1) 2006: 22 trials (Observational 8, Phase 4 7, Phase 3 5, Phase 2 1, Phase 1 1) 2007: 26 trials (Observational 12, Not applicable 2, Phase 4 6, Phase 3 2, Phase 2/3 1, Phase 2 2, Phase 1 1) 2008: 30 trials (Observational 10, Not applicable 2, Phase 4 10, Phase 3 4, Phase 2/3 1, Phase 2 2, Phase 1 1) 2009: 26 trials (Observational 8, Not applicable 2, Phase 4 3, Phase 3 5, Phase 2 6, Phase 1/2 1, Phase 1 1) 2010: 37 trials (Observational 11, Not applicable 1, Phase 4 5, Phase 3 14, Phase 2 5, Phase 1 1) 2011: 32 trials (Observational 13, Not applicable 4, Phase 4 2, Phase 3 7, Phase 2 4, Phase 1 2) 2012: 34 trials (Observational 16, Not applicable 4, Phase 4 3, Phase 3 9, Phase 2 1, Phase 1 1) 2013: 41 trials (Observational 16, Not applicable 10, Phase 4 3, Phase 3 9, Phase 2 3) 2014: 47 trials (Observational 11, Not applicable 10, Phase 4 6, Phase 3 14, Phase 2 2, Phase 1/2 1, Phase 1 3) 2015: 68 trials (Observational 30, Not applicable 14, Phase 4 3, Phase 3 12, Phase 2 8, Phase 1 1) 2016: 61 trials (Observational 15, Not applicable 11, Phase 4 13, Phase 3 14, Phase 2/3 1, Phase 2 7) 2017: 71 trials (Observational 23, Not applicable 17, Phase 4 4, Phase 3 12, Phase 2/3 2, Phase 2 10, Phase 1/2 1, Phase 1 2) 2018: 63 trials (Observational 25, Not applicable 16, Phase 4 9, Phase 3 5, Phase 2/3 1, Phase 2 3, Phase 1 4) 2019: 82 trials (Observational 34, Not applicable 19, Phase 4 8, Phase 3 14, Phase 2 3, Phase 1 4) 2020: 69 trials (Observational 33, Not applicable 18, Phase 4 2, Phase 3 7, Phase 2/3 1, Phase 2 6, Phase 1 2) 2021: 93 trials (Observational 40, Not applicable 24, Phase 4 7, Phase 3 9, Phase 2/3 1, Phase 2 6, Phase 1/2 2, Phase 1 4) 2022: 75 trials (Observational 34, Not applicable 22, Phase 4 3, Phase 3 3, Phase 2/3 1, Phase 2 7, Phase 1 5) 2023: 72 trials (Observational 35, Not applicable 17, Phase 4 6, Phase 3 10, Phase 2 3, Phase 1 1) 2024: 75 trials (Observational 27, Not applicable 26, Phase 4 3, Phase 3 8, Phase 2/3 1, Phase 2 6, Phase 1 4) 2025: 76 trials (Observational 30, Not applicable 24, Phase 4 7, Phase 3 7, Phase 2/3 1, Phase 2 3, Phase 1/2 2, Phase 1 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 71
2025 76
2024 75
2023 72
2022 75
2021 93
2020 69
2019 82
2018 63
2017 71

Forecast of the full-year count, planned starts included, not rows of this table: about 87 trials starting in 2026 and about 78 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 104 trials still running at the 2026-10-09 snapshot; registered median of 22 months across 780 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Spondylarthritis trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 46
Phase 1/2 9
Phase 2 108
Phase 2/3 15
Phase 3 191
Phase 4 132
Not applicable 266
Observational 487
Expanded access 2

How many Spondylarthritis trials are recruiting? (11)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 66
Recruiting 153
Enrolling by invitation 10
Active, not recruiting 50
Available 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Spondylarthritis trials? (12)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Novartis Pharmaceuticals 47
Pfizer 39
AbbVie 36
Amgen 23
Janssen Research & Development, LLC 23

Which drugs are being tested for Spondylarthritis? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
INFLIXIMAB 39
(CP-6890,550) Tofacitinib 19

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
1=Etanercept 64
Adalimumab-US 63
Secukinmab 56
HD- Methotrexate (MTX) 31
SC golimumab 29

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Spondylarthritis trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 245 80
Osteoarthritis 224 68
Cholelithiasis 111 49
Atrial fibrillation 104 41
Myocardial infarction 99 45

Which publications cover Spondylarthritis? (273)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages