Condition (MeSH)
Metatarsalgia
ClinicalTrials.gov lists 45 trials for Metatarsalgia or a narrower condition beneath it. Centrexion Therapeutics has the most among industry and government lead sponsors, with 3.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
22 of the 45 trials are tagged with Metatarsalgia itself; the rest are tagged with a narrower condition beneath it.
When did Metatarsalgia trials start? (18)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 4
- Not applicable
- Observational
Top of scale: 8
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 4 |
| 2024 | 1 |
| 2023 | 2 |
| 2022 | 8 |
| 2021 | 4 |
| 2019 | 2 |
| 2018 | 3 |
| 2016 | 3 |
| 2015 | 3 |
Showing 10 of 18 earlier years.
No forecast is made for this condition: it averages 3.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 27 months from start to primary completion across 5 trials still running at the 2026-10-09 snapshot; registered median of 9 months across 31 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Metatarsalgia trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 4 |
| Phase 4 | 1 |
| Not applicable | 28 |
| Observational | 7 |
How many Metatarsalgia trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 3 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 29 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Metatarsalgia trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Centrexion Therapeutics | 3 |
| AlgoRx Pharmaceuticals | 1 |
| AstraZeneca | 1 |
| Axogen Corporation | 1 |
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Capsaicin 8% | 3 |
| Cryoablation | 2 |
| L:Lidocaine | 2 |
| NAC 0mg/day (Placebo) | 1 |
| Injection of Steroid into Foot | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Metatarsalgia trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| ABORTION SPONTANEOUS | 1 | 1 |
| ACUTE MYOCARDIAL INFARCTION | 1 | 1 |
| APPENDICITIS | 1 | 1 |
| CEREBROVASCULAR ACCIDENT | 1 | 1 |
| COVID-19 PNEUMONIA | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Metatarsalgia? (12)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Custom foot orthoses for chronic metatarsalgia: Study protocol for a participant- and assessor-blinded superiority randomized controlled trial. | PloS one | 2026 | Yes |
| A Predictive Model for Gastrocnemius Tightness in Forefoot Pain and Intractable Plantar Keratosis of the Second Rocker. | Journal of the American Podiatric Medical Association | 2021 | Yes |
| Distal Minimally Invasive Metatarsal Osteotomy ("DMMO" Procedure). | Foot and ankle clinics | 2019 | Yes |
| Plantar pressure analysis of accommodative insole in older people with metatarsalgia. | Gait & posture | 2014 | Yes |
| Interdigital neuralgia. | Foot and ankle clinics | 2011 | Yes |
Showing 5 of 12 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.