Condition (MeSH)
DNA Repair-Deficiency Disorders
ClinicalTrials.gov lists 373 trials for DNA Repair-Deficiency Disorders or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 17.
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Trials per phase (log scale)
1 more section with rows
8 of the 373 trials are tagged with DNA Repair-Deficiency Disorders itself; the rest are tagged with a narrower condition beneath it.
When did DNA Repair-Deficiency Disorders trials start? (36)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 26
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 18 |
| 2025 | 26 |
| 2024 | 19 |
| 2023 | 18 |
| 2022 | 20 |
| 2021 | 14 |
| 2020 | 20 |
| 2019 | 15 |
| 2018 | 22 |
| 2017 | 18 |
Showing 10 of 36 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 18 trials starting in 2026 and about 23 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 18 already registered with a 2026 start date: at the cutoff, 6 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.
Prediction, not a registry value: median of 36 months from start to primary completion across 31 trials still running at the 2026-10-09 snapshot; registered median of 44 months across 179 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are DNA Repair-Deficiency Disorders trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 33 |
| Phase 1/2 | 34 |
| Phase 2 | 50 |
| Phase 2/3 | 2 |
| Phase 3 | 15 |
| Phase 4 | 3 |
| Not applicable | 86 |
| Observational | 147 |
| Expanded access | 3 |
How many DNA Repair-Deficiency Disorders trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 17 |
| Recruiting | 74 |
| Enrolling by invitation | 10 |
| Active, not recruiting | 24 |
| Available | 2 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most DNA Repair-Deficiency Disorders trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Cancer Institute (NCI) | 17 |
| National Heart, Lung, and Blood Institute (NHLBI) | 9 |
| National Human Genome Research Institute (NHGRI) | 7 |
| National Institute of Allergy and Infectious Diseases (NIAID) | 5 |
Which drugs are being tested for DNA Repair-Deficiency Disorders? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Cytoxan | 21 |
| Busulfan | 15 |
| Melphalan | 9 |
| METHYLPREDNISOLONE | 9 |
| G-CSF | 5 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| SQ Fludarabine | 26 |
| Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)] | 13 |
| Total Body Irradiation | 10 |
| Filgrastime (G-CSF) | 9 |
| Allogeneic bone marrow transplantation | 9 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do DNA Repair-Deficiency Disorders trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Diarrhea | 58 | 2 |
| Hypertension | 49 | 1 |
| Hypokalemia | 45 | 1 |
| Pyrexia | 37 | 7 |
| Thromboembolic event | 29 | 1 |
Showing 5 of 10 adverse events.
Which publications cover DNA Repair-Deficiency Disorders? (5)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Current Understanding and Future Research Priorities in Malignancy Associated With Inborn Errors of Immunity and DNA Repair Disorders: The Perspective of an Interdisciplinary Working Group. | Frontiers in immunology | 2018 | Yes |
| [DNA repair and repair diseases: between molecular models and clinical reality]. | Bulletin du cancer | 2011 | Yes |
| DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome. | Histopathology | 2010 | Yes |
| Tuberous sclerosis complex and DNA repair. | Advances in experimental medicine and biology | 2010 | Yes |
| Inherited defects of immunoglobulin class switch recombination. | Advances in experimental medicine and biology | 2010 | Yes |
Sub-conditions in MeSH (11)
MeSH descendants one level down with at least one trial, most trials first.
+1 more sub-condition
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.