Condition (MeSH)
Familial Hypophosphatemic Rickets
ClinicalTrials.gov lists 49 trials for Familial Hypophosphatemic Rickets or a narrower condition beneath it. Kyowa Kirin Co., Ltd. has the most among industry and government lead sponsors, with 10.
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Trials per phase
49 of the 49 trials are tagged with Familial Hypophosphatemic Rickets itself; the rest are tagged with a narrower condition beneath it.
When did Familial Hypophosphatemic Rickets trials start? (20)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 2 |
| 2024 | 2 |
| 2022 | 1 |
| 2021 | 6 |
| 2020 | 4 |
| 2019 | 6 |
| 2018 | 5 |
| 2017 | 3 |
| 2016 | 2 |
Showing 10 of 20 earlier years.
No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Familial Hypophosphatemic Rickets trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 5 |
| Phase 1/2 | 5 |
| Phase 2 | 3 |
| Phase 3 | 8 |
| Phase 4 | 5 |
| Not applicable | 5 |
| Observational | 17 |
| Expanded access | 1 |
How many Familial Hypophosphatemic Rickets trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 4 |
| Active, not recruiting | 4 |
| Available | 1 |
| Completed | 31 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Familial Hypophosphatemic Rickets trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Kyowa Kirin Co., Ltd. | 10 |
| Kyowa Kirin, Inc. | 6 |
| Kyowa Kirin Pharmaceutical Development Ltd | 5 |
| Medialis Ltd. | 1 |
| Novo Nordisk A/S | 1 |
Which drugs are being tested for Familial Hypophosphatemic Rickets? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Burosumab | 19 |
| Calcitriol | 2 |
| Cinacalcet | 2 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Burosumab Injection [Crysvita] | 1 |
| Oral Magnesium Supplement | 1 |
| No treatment given | 1 |
| Active vitamin D | 1 |
| norditropine simplex | 1 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Familial Hypophosphatemic Rickets trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Arthralgia | 4 | 1 |
| Craniosynostosis | 4 | 1 |
| Migraine | 4 | 2 |
| Myelopathy | 4 | 1 |
| Cervical Spinal Stenosis | 3 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Familial Hypophosphatemic Rickets? (45)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Advancing Patient Evidence in XLH (APEX): Baseline analysis of a global data unification program. | Bone | 2025 | Yes |
| Prevalence of Comorbid Hyperparathyroidism and Its Association with Renal Dysfunction in Asian Patients with X-Linked Hypophosphatemic Rickets/Osteomalacia. | Calcified tissue international | 2025 | Yes |
| Nephrocalcinosis and kidney function in children and adults with X-linked hypophosphatemia: baseline results from a large longitudinal study. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 2024 | Yes |
| A patient-centred and multi-stakeholder co-designed observational prospective study protocol: Example of the adolescent experience of treatment for X-linked hypophosphataemia (XLH). | PloS one | 2024 | Yes |
| Self-Administration of Burosumab in Children and Adults with X-Linked Hypophosphataemia in Two Open-Label, Single-Arm Clinical Studies. | Advances in therapy | 2023 | Yes |
Showing 5 of 45 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.