Condition (MeSH)
Desmoplastic Small Round Cell Tumor
ClinicalTrials.gov lists 58 trials for Desmoplastic Small Round Cell Tumor or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 6.
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Trials per phase (log scale)
58 of the 58 trials are tagged with Desmoplastic Small Round Cell Tumor itself; the rest are tagged with a narrower condition beneath it.
When did Desmoplastic Small Round Cell Tumor trials start? (29)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 3 |
| 2024 | 3 |
| 2023 | 1 |
| 2022 | 2 |
| 2021 | 3 |
| 2020 | 5 |
| 2019 | 5 |
| 2018 | 1 |
| 2017 | 2 |
Showing 10 of 29 earlier years.
No forecast is made for this condition: it averages 2.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 15 trials still running at the 2026-10-09 snapshot; registered median of 53 months across 28 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Desmoplastic Small Round Cell Tumor trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 17 |
| Phase 1/2 | 8 |
| Phase 2 | 23 |
| Phase 2/3 | 1 |
| Phase 3 | 1 |
| Not applicable | 2 |
| Observational | 5 |
| Expanded access | 1 |
How many Desmoplastic Small Round Cell Tumor trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 12 |
| Active, not recruiting | 5 |
| Completed | 27 |
| Terminated | 6 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Desmoplastic Small Round Cell Tumor trials? (8)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Cancer Institute (NCI) | 6 |
| Children's Oncology Group | 4 |
| European Organisation for Research and Treatment of Cancer - EORTC | 2 |
| Salarius Pharmaceuticals, LLC | 2 |
| Amgen | 1 |
Showing 5 of 8 sponsors.
Which drugs are being tested for Desmoplastic Small Round Cell Tumor? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Cytoxan | 9 |
| Thiotepa | 3 |
| Melphalan | 3 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Doxorubicine | 9 |
| Etoposid | 7 |
| Vincristina | 7 |
| Ifosfamid | 6 |
| Filgrastime (G-CSF) | 5 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Desmoplastic Small Round Cell Tumor trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Death: Death not associated with CTCAE term: Disease progression NOS | 29 | 1 |
| Fever | 8 | 2 |
| Alanine aminotransferase increased | 6 | 3 |
| Vomiting | 6 | 3 |
| Aspartate aminotransferase increased | 5 | 3 |
Showing 5 of 10 adverse events.
Which publications cover Desmoplastic Small Round Cell Tumor? (34)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Rationale and design of the PAMSARC (pasireotide as maintenance treatment with monthly deep intramuscular injection in SSTR2/3/5-expressing synovial sarcoma and desmoplastic small round cell tumor) multicenter phase 2 trial. | Cancer treatment and research communications | 2025 | Yes |
| Trabectedin-irinotecan, a potentially promising combination in relapsed desmoplastic small round cell tumor: report of two cases. | Journal of chemotherapy (Florence, Italy) | 2023 | Yes |
| Long-term survivors with desmoplastic small round cell tumor (DSRCT): Results from a retrospective single-institution case series analysis. | Cancer medicine | 2023 | Yes |
| Effectiveness of irinotecan plus trabectedin on a desmoplastic small round cell tumor patient-derived xenograft. | Disease models & mechanisms | 2023 | Yes |
| Multiagent chemotherapy including IrIVA regimen and maintenance therapy in the treatment of desmoplastic small round cell tumor. | Tumori | 2022 | Yes |
Showing 5 of 34 publications.
Prevalence (9)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Desmoplastic small round cell tumor | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| Desmoplastic small round cell tumor | Annual incidence | <1 / 1 000 000 | Europe | Not stated | Exact |
| Desmoplastic small round cell tumor | Annual incidence | <1 / 1 000 000 | Europe | Not stated | Exact |
| Desmoplastic small round cell tumor | Cases families | Worldwide | Not stated | Exact | |
| Desmoplastic small round cell tumor | Cases families | Worldwide | Not stated | Unspecified |
Showing 5 of 9 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Desmoplastic small round cell tumor | 83469 | Exact | Orphadata Science knowledge files, Product 1 |
| Desmoplastic small round cell tumor | 83469 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.