Clinical trial
DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations. Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High TMB or MSI-high or Proven CMMRD Disposition.
NCT05770102 is registered in ClinicalTrials.gov with Cancer Research UK as lead sponsor.
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Registry record
As filed in ClinicalTrials.gov.
- Title
- DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations. Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High TMB or MSI-high or Proven CMMRD Disposition.
- Lead sponsor
- Cancer Research UK
- Phase
- Phase 2/3
- Overall status
- Recruiting
- Start date
- October 25, 2023
- Completion date
- October 31, 2029
- Enrollment
- 30 (estimated)
- Sites
- 27
Conditions
As the registry lists them; a condition with its own page is linked.
cancer, colorectal neoplasms, endometrial neoplasms, lymphoproliferative disorders, malignancy, malignant neoplasm, melanoma, neoplasms by histologic type, neoplasms by site, solid tumours