Gene
RAC1
RAC1 is a gene biomarker in the evidence tier "Cancer actionable (CGI)". This page lists evidence by type: Assay-provider ledger (10), Actionable biomarkers (1), Target-disease associations (447), and 5 more evidence types, each linked to its source.
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Rows recorded per section (log scale)
4 sections measured, none recorded
Cancer actionable (CGI)
Evidence over time
Share of that year: what fraction of the papers our biomarker dictionary matched in a year mention RAC1. The denominator is documents that mention any gene, not every registered document, so improving the matcher moves both halves and never rewrites history. Actionable-biomarker and target-disease-association evidence carries no date in our sources, so it is not on this chart. Publication mentions cover only papers cited by a registered clinical trial, not all of PubMed.
Publication mentions: plotted from 1990 to 2023, the years our matched corpus covers. Not plotted: 1 at the structurally incomplete recent edge.
The yearly numbers
| Year | Publication mentions | Share of that year |
|---|---|---|
| 2023 | 16 of 11,460 | 0.14% |
| 2022 | 27 of 13,598 | 0.20% |
| 2021 | 19 of 15,045 | 0.13% |
| 2020 | 10 of 14,459 | 0.07% |
| 2019 | 22 of 12,159 | 0.18% |
| 2018 | 28 of 11,854 | 0.24% |
| 2017 | 15 of 11,595 | 0.13% |
| 2016 | 14 of 10,983 | 0.13% |
| 2015 | 21 of 11,395 | 0.18% |
| 2014 | 19 of 10,367 | 0.18% |
Showing 10 of 34 years.
Assay-provider ledger (10)
Shown in this order: most recent publication first.
| Company | Provider class | Validation | Papers | Most recent publication |
|---|---|---|---|---|
| BECKMAN COULTER | Context dependent | Clinical validationAnalytical validation | 1 | March 29, 2017 |
| QIAGEN | Reagent supplier | Clinical validationAnalytical validation | 1 | March 29, 2017 |
| THERMO FISHER SCIENTIFIC (Click-iT EdU kit, TaqMan Low-Density Array reagents, ExpressionSuite/DataAssist software) | Reagent supplier | Clinical validationAnalytical validation | 1 | March 29, 2017 |
| BIORAD | Reagent supplier | Analytical validation | 1 | December 09, 2015 |
| Center for Biotechnology, Bielefeld University | Not a company | Analytical validation | 1 | December 09, 2015 |
Showing 5 of 10 assay-provider companies.
Actionable biomarkers (1)
Shown in this order: fixed catalogue order, not ranked.
| Alteration | Drug | Response | Disease | Source |
|---|---|---|---|---|
| RAC1 (P29S) + BRAF oncogenic mutation | Braf Inhibitors | responsive | cutaneous melanoma | Cancer Genome Interpreter |
Target-disease associations (447)
Shown in this order: fixed catalogue order, not ranked.
| Disease | Therapeutic area | Source |
|---|---|---|
| Abnormality of the skeletal system | phenotype | GWAS credible sets |
| Adult-onset autosomal recessive sideroblastic anemia | genetic, familial or congenital disease | Mouse knockout (IMPC) |
| Alphavirus infectious disease | infectious disease | Literature (Europe PMC) |
| Alzheimer disease | nervous system disease | Literature (Europe PMC) |
| Alzheimer disease | nervous system disease | GWAS credible sets |
Showing 5 of 447 associations.
Vendor sourcing (12)
Shown in this order: alphabetical by organization.
| Organization | Role | Tier | Evidence | Citation |
|---|---|---|---|---|
| 3billion, Inc. (South Korea) | Testing lab / CRO (runs the assay) | Clinical-testing interpretation submitted (ClinVar)ClinVar clinical-testing submission | A different missense change at the same codon has been reported as pathogenic/likely pathogenic with strong evidence (ClinVar ID: VCV000445283, PM5_M). In si... | View ClinVar record SCV002059157.1 |
| Ambry Genetics (United States) | Testing lab / CRO (runs the assay) | Clinical-testing interpretation submitted (ClinVar)ClinVar clinical-testing submission | The c.77A>G (p.N26S) alteration is located in exon 2 (coding exon 2) of the RAC1 gene. This alteration results from an A to G substitution at nucleotide posi... | View ClinVar record SCV001445795.4 |
| Baylor College of Medicine | Testing lab / CRO (runs the assay) | Clinical-testing interpretation submitted (ClinVar)ClinVar clinical-testing submission | No supporting text recorded; see the citation. | View ClinVar record SCV004102736.1 |
| DASA (Brazil) | Testing lab / CRO (runs the assay) | Clinical-testing interpretation submitted (ClinVar)ClinVar clinical-testing submission | NM_006908.5(RAC1):c.304C>T (p.Arg102Trp) is a missense variant that results in the substitution of arginine with tryptophan. This variant is rare in populati... | View ClinVar record SCV007657425.2 |
| GeneDx Holdings Corp. | Testing lab / CRO (runs the assay) | Clinical-testing interpretation submitted (ClinVar)ClinVar clinical-testing submission | Not observed in large population cohorts (Lek et al., 2016); In silico analysis, which includes protein predictors and evolutionary conservation, supports a ... | View ClinVar record SCV000618281.4 |
Showing 5 of 12 sourcing records.
Trial-cited literature (263)
Shown in this order: newest first, then most cited.
| Publication | Journal | Year | Citations |
|---|---|---|---|
| MicroRNAs in Liver Cirrhosis: Diagnostic and Therapeutic Perspectives-A Comprehensive Review. | Journal of personalized medicine | 2025 | 1 |
| YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches. | Nature cancer | 2023 | 286 |
| Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment. | Frontiers in endocrinology | 2023 | 212 |
| The evolution of non-small cell lung cancer metastases in TRACERx. | Nature | 2023 | 191 |
| Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy. | International journal of molecular sciences | 2023 | 151 |
Showing 5 of 263 papers.
Protein variant mentions (10)
Shown in this order: alphabetical by variant.
| Variant | Distinct papers | Year range | Sample papers |
|---|---|---|---|
| p.D124E | 1 | 2015 | PMID 25741868 |
| p.E156A | 1 | 2019 | PMID 31216465 |
| p.F169C | 1 | 2015 | PMID 25741868 |
| p.N39S | 1 | 2015 | PMID 25741868 |
| p.N92I | 1 | 2021 | PMID 34607932 |
Showing 5 of 10 variants.
Literature-extracted relations (22)
Shown in this order: chemicals, then diseases.
| Related entity | Kind | Source relation label | Paper | Year |
|---|---|---|---|---|
| DOXORUBICIN | Chemical | associate |
Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature. | 2020 |
| Imatinib | Chemical | positive_correlate |
Effective treatment of edema and endothelial barrier dysfunction with imatinib. | 2012 |
| ATORVASTATIN | Chemical | negative_correlate |
Immediate antioxidant and antiplatelet effect of atorvastatin via inhibition of Nox2. | 2012 |
| MORPHINE | Chemical | negative_correlate |
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms. | 2012 |
| ATORVASTATIN | Chemical | associate |
Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. | 2012 |
Showing 5 of 22 relation assertions.
Organizations publishing (278)
Shown in this order: most papers first.
| Organization | Type | Papers | Years |
|---|---|---|---|
| Harvard Medical School | Academic | 14 | 2009 to 2023 |
| Government of the United States of America | Government | 10 | 2009 to 2021 |
| Mass General Brigham | Hospital | 10 | 2010 to 2023 |
| University of California System | Academic | 9 | 2009 to 2022 |
| University of Oxford | Academic | 8 | 2010 to 2022 |
Showing 5 of 278 organizations.
Where RAC1 appears
- animal disease
- biological_process
- cancer or benign tumor
- cardiovascular disease
- disorder of visual system
- endocrine system disease
- gastrointestinal disease
- genetic, familial or congenital disease
- hematologic disease
- immune system disease
- infectious disease
- injury, poisoning or other complication
- integumentary system disease
- measurement
- musculoskeletal or connective tissue disease
- nervous system disease
- nutritional or metabolic disease
- phenotype
- reproductive system or breast disease
- respiratory or thoracic disease
- urinary system disease
401 diseases touched.
Not on this page
Checked, with nothing recorded for this biomarker: fda companion diagnostic assertions, fda biomarker qualification projects, trial mentions, and human sample screening reference.