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Condition (MeSH)

Adenocarcinoma

ClinicalTrials.gov lists 8,205 trials for Adenocarcinoma or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 329.

MeSH D000230 Neoplasms Neoplasm C04
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Phase 1 Phase 1 1,180 Phase 1/2 Phase 1/2 656 Phase 2 Phase 2 2,446 Phase 2/3 Phase 2/3 118 Phase 3 Phase 3 570 Phase 4 Phase 4 168 Not applicable Not applicable 1,296 Observational Observational 1,736 Phase 1 Phase 1 1,180 Phase 1/2 Phase 1/2 656 Phase 2 Phase 2 2,446 Phase 2/3 Phase 2/3 118 Phase 3 Phase 3 570 Phase 4 Phase 4 168 Not applicable Not applicable 1,296 Observational Observational 1,736

Trials per phase (log scale)

2 more sections with rows

617 of the 8,205 trials are tagged with Adenocarcinoma itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Adenocarcinoma trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 17 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 515

1990: 1 trials (Observational 1) 1991: 3 trials (Observational 1, Phase 3 1, Phase 2 1) 1992: 1 trials (Phase 3 1) 1993: 4 trials (Observational 2, Not applicable 1, Phase 2 1) 1994: 10 trials (Not applicable 1, Phase 3 3, Phase 2 3, Phase 1 3) 1995: 10 trials (Observational 3, Phase 3 1, Phase 2 5, Phase 1/2 1) 1996: 12 trials (Observational 2, Phase 3 2, Phase 2/3 1, Phase 2 4, Phase 1/2 1, Phase 1 2) 1997: 25 trials (Observational 3, Phase 3 7, Phase 2 8, Phase 1/2 2, Phase 1 5) 1998: 40 trials (Phase 3 6, Phase 2 20, Phase 1/2 5, Phase 1 9) 1999: 42 trials (Observational 2, Not applicable 3, Phase 3 5, Phase 2 19, Phase 1/2 1, Phase 1 12) 2000: 65 trials (Observational 12, Phase 4 1, Phase 3 12, Phase 2 20, Phase 1/2 6, Phase 1 14) 2001: 75 trials (Observational 8, Not applicable 4, Phase 4 1, Phase 3 6, Phase 2/3 1, Phase 2 31, Phase 1/2 10, Phase 1 14) 2002: 81 trials (Observational 6, Not applicable 2, Phase 3 9, Phase 2/3 2, Phase 2 45, Phase 1/2 6, Phase 1 11) 2003: 85 trials (Observational 9, Not applicable 12, Phase 4 1, Phase 3 8, Phase 2/3 2, Phase 2 37, Phase 1/2 7, Phase 1 9) 2004: 142 trials (Observational 17, Not applicable 10, Phase 4 1, Phase 3 12, Phase 2/3 2, Phase 2 69, Phase 1/2 11, Phase 1 20) 2005: 159 trials (Other 1, Observational 15, Not applicable 13, Phase 4 3, Phase 3 17, Phase 2/3 3, Phase 2 73, Phase 1/2 14, Phase 1 20) 2006: 189 trials (Observational 22, Not applicable 14, Phase 4 6, Phase 3 17, Phase 2/3 2, Phase 2 88, Phase 1/2 11, Phase 1 29) 2007: 231 trials (Other 2, Observational 33, Not applicable 29, Phase 4 10, Phase 3 18, Phase 2/3 5, Phase 2 95, Phase 1/2 10, Phase 1 29) 2008: 251 trials (Observational 58, Not applicable 33, Phase 4 9, Phase 3 20, Phase 2/3 3, Phase 2 82, Phase 1/2 14, Phase 1 32) 2009: 254 trials (Observational 44, Not applicable 31, Phase 4 5, Phase 3 22, Phase 2/3 5, Phase 2 77, Phase 1/2 23, Phase 1 47) 2010: 237 trials (Observational 52, Not applicable 29, Phase 4 8, Phase 3 25, Phase 2/3 1, Phase 2 65, Phase 1/2 21, Phase 1 36) 2011: 249 trials (Observational 56, Not applicable 32, Phase 4 12, Phase 3 21, Phase 2/3 2, Phase 2 77, Phase 1/2 18, Phase 1 31) 2012: 258 trials (Other 1, Observational 46, Not applicable 49, Phase 4 9, Phase 3 12, Phase 2/3 7, Phase 2 75, Phase 1/2 15, Phase 1 44) 2013: 227 trials (Observational 41, Not applicable 47, Phase 4 8, Phase 3 19, Phase 2/3 5, Phase 2 57, Phase 1/2 17, Phase 1 33) 2014: 289 trials (Observational 60, Not applicable 54, Phase 4 10, Phase 3 18, Phase 2/3 5, Phase 2 69, Phase 1/2 26, Phase 1 47) 2015: 317 trials (Other 1, Observational 66, Not applicable 65, Phase 4 14, Phase 3 17, Phase 2/3 8, Phase 2 80, Phase 1/2 25, Phase 1 41) 2016: 338 trials (Observational 73, Not applicable 63, Phase 4 10, Phase 3 32, Phase 2/3 1, Phase 2 77, Phase 1/2 33, Phase 1 49) 2017: 345 trials (Observational 55, Not applicable 68, Phase 4 4, Phase 3 27, Phase 2/3 2, Phase 2 100, Phase 1/2 38, Phase 1 51) 2018: 377 trials (Observational 97, Not applicable 64, Phase 4 4, Phase 3 25, Phase 2/3 3, Phase 2 101, Phase 1/2 31, Phase 1 52) 2019: 437 trials (Observational 104, Not applicable 66, Phase 4 5, Phase 3 39, Phase 2/3 12, Phase 2 107, Phase 1/2 41, Phase 1 63) 2020: 439 trials (Observational 96, Not applicable 88, Phase 4 4, Phase 3 21, Phase 2/3 4, Phase 2 123, Phase 1/2 31, Phase 1 72) 2021: 470 trials (Observational 112, Not applicable 78, Phase 4 6, Phase 3 22, Phase 2/3 5, Phase 2 135, Phase 1/2 38, Phase 1 74) 2022: 491 trials (Observational 152, Not applicable 80, Phase 4 4, Phase 3 21, Phase 2/3 7, Phase 2 118, Phase 1/2 40, Phase 1 69) 2023: 469 trials (Observational 102, Not applicable 84, Phase 4 10, Phase 3 28, Phase 2/3 9, Phase 2 124, Phase 1/2 51, Phase 1 61) 2024: 502 trials (Observational 151, Not applicable 85, Phase 4 6, Phase 3 14, Phase 2/3 6, Phase 2 146, Phase 1/2 31, Phase 1 63) 2025: 515 trials (Observational 134, Not applicable 98, Phase 4 8, Phase 3 22, Phase 2/3 8, Phase 2 138, Phase 1/2 37, Phase 1 70)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 478
2025 515
2024 502
2023 469
2022 491
2021 470
2020 439
2019 437
2018 377
2017 345

Forecast of the full-year count, planned starts included, not rows of this table: about 590 trials starting in 2026 and about 530 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 1,148 trials still running at the 2026-10-09 snapshot; registered median of 37 months across 4,294 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Adenocarcinoma trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1,180
Phase 1/2 656
Phase 2 2,446
Phase 2/3 118
Phase 3 570
Phase 4 168
Not applicable 1,296
Observational 1,736
Expanded access 34
Unknown 1

How many Adenocarcinoma trials are recruiting? (12)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 435
Recruiting 1,331
Enrolling by invitation 45
Active, not recruiting 543
Available 5

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Adenocarcinoma trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 329
Pfizer 90
Novartis Pharmaceuticals 79
Bayer 64

Which drugs are being tested for Adenocarcinoma? (8)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Sorafenib 273
PEMBROLIZUMAB 253
NIVOLUMAB 227
TACE 116
(nab)-paclitaxel 115

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Bevacizumab 1 228
Gemcitabine/Gemzar 178
Lenvatinib 1 177
Cisplatin 1 149
Sunitinib 4/2 149

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Adenocarcinoma trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 2,389 317
Fatigue 1,881 358
Vomiting 1,844 418
Abdominal pain 1,799 361
Malignant neoplasm progression 1,685 86

Which publications cover Adenocarcinoma? (4,546)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (28)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages