Condition (MeSH)
Chordoma
ClinicalTrials.gov lists 62 trials for Chordoma or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 6.
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Trials per phase
62 of the 62 trials are tagged with Chordoma itself; the rest are tagged with a narrower condition beneath it.
When did Chordoma trials start? (24)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 6
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 4 |
| 2023 | 5 |
| 2022 | 4 |
| 2021 | 1 |
| 2020 | 4 |
| 2019 | 5 |
| 2018 | 3 |
| 2017 | 6 |
| 2016 | 3 |
Showing 10 of 24 earlier years.
No forecast is made for this condition: it averages 3.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 57 months across 32 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Chordoma trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 12 |
| Phase 1/2 | 7 |
| Phase 2 | 19 |
| Phase 3 | 1 |
| Not applicable | 9 |
| Observational | 13 |
| Expanded access | 1 |
How many Chordoma trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 8 |
| Active, not recruiting | 10 |
| Available | 1 |
| Completed | 28 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Chordoma trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Cancer Institute (NCI) | 6 |
| Novartis Pharmaceuticals | 3 |
| Bavarian Nordic | 2 |
| Children's Oncology Group | 2 |
| BioMed Valley Discoveries, Inc | 1 |
Which drugs are being tested for Chordoma? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| NIVOLUMAB | 6 |
| IPILIMUMAB | 3 |
| CETUXIMAB | 3 |
| Imatinib | 2 |
| PEMBROLIZUMAB | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Palbociclib Pill | 2 |
| ERAS-601 | 2 |
| DNG64-CAR-V | 1 |
| Camrelizumab and Apatinib | 1 |
| polyvinylpyrrolidone-sodium hyaluronate gel | 1 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Chordoma trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Dyspnea | 34 | 1 |
| Pleural effusion | 31 | 2 |
| Nausea | 19 | 2 |
| Vomiting | 19 | 2 |
| Musculo. Pain | 17 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Chordoma? (101)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Activity of pemetrexed in pre-clinical chordoma models and humans. | Scientific reports | 2023 | Yes |
| Chordoma. | Archives of pathology & laboratory medicine | 2022 | Yes |
| Chordoma: Current status, problems, and future directions. | Current problems in cancer | 2021 | Yes |
| Surgical treatment of primary mobile spine chordoma. | Journal of surgical oncology | 2021 | Yes |
| The Efficacy of Radiofrequency Ablation for Bone Tumors Unsuitable for Radical Excision. | Clinics in orthopedic surgery | 2021 | Yes |
Showing 5 of 101 publications.
Prevalence (3)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Chordoma | Annual incidence | <1 / 1 000 000 | United States | US | Exact |
| Chordoma | Annual incidence | <1 / 1 000 000 | United States | US | Exact |
| Chordoma | Annual incidence | <1 / 1 000 000 | United States | US | Unspecified |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Chordoma | 178 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Chordoma | 178 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.