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Condition (MeSH)

Spondylitis, Ankylosing

ClinicalTrials.gov lists 515 trials for Spondylitis, Ankylosing or a narrower condition beneath it.

MeSH D013167 Musculoskeletal Diseases C05 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 16 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 43 Phase 2/3 Phase 2/3 9 Phase 3 Phase 3 73 Phase 4 Phase 4 58 Not applicable Not applicable 94 Observational Observational 216 Phase 1 Phase 1 16 Phase 1/2 Phase 1/2 5 Phase 2 Phase 2 43 Phase 2/3 Phase 2/3 9 Phase 3 Phase 3 73 Phase 4 Phase 4 58 Not applicable Not applicable 94 Observational Observational 216

Trials per phase (log scale)

1 more section with rows

515 of the 515 trials are tagged with Spondylitis, Ankylosing itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Spondylitis, Ankylosing trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 32

1995: 1 trials (Observational 1) 1996: 1 trials (Phase 2 1) 1997: 1 trials (Not applicable 1) 1998: 1 trials (Not applicable 1) 1999: 2 trials (Observational 1, Phase 2 1) 2000: 1 trials (Observational 1) 2001: 1 trials (Phase 3 1) 2002: 8 trials (Phase 4 1, Phase 3 4, Phase 2/3 2, Phase 2 1) 2003: 8 trials (Observational 4, Phase 3 3, Phase 2 1) 2004: 13 trials (Observational 6, Phase 4 4, Phase 3 2, Phase 2 1) 2005: 11 trials (Observational 2, Not applicable 1, Phase 4 3, Phase 3 2, Phase 2/3 1, Phase 2 1, Phase 1/2 1) 2006: 11 trials (Observational 5, Phase 4 4, Phase 3 2) 2007: 16 trials (Observational 8, Phase 4 4, Phase 3 2, Phase 2/3 1, Phase 1 1) 2008: 20 trials (Observational 6, Not applicable 1, Phase 4 8, Phase 3 2, Phase 2/3 1, Phase 2 2) 2009: 17 trials (Observational 8, Phase 4 2, Phase 3 3, Phase 2 3, Phase 1 1) 2010: 20 trials (Observational 7, Phase 4 2, Phase 3 7, Phase 2 3, Phase 1 1) 2011: 19 trials (Observational 9, Not applicable 3, Phase 4 1, Phase 3 3, Phase 2 2, Phase 1 1) 2012: 23 trials (Observational 13, Not applicable 2, Phase 4 2, Phase 3 4, Phase 2 1, Phase 1 1) 2013: 16 trials (Observational 8, Not applicable 2, Phase 4 2, Phase 3 2, Phase 2 2) 2014: 22 trials (Observational 6, Not applicable 5, Phase 4 2, Phase 3 4, Phase 2 2, Phase 1/2 1, Phase 1 2) 2015: 25 trials (Observational 11, Not applicable 4, Phase 4 3, Phase 3 5, Phase 2 1, Phase 1 1) 2016: 28 trials (Observational 7, Not applicable 3, Phase 4 5, Phase 3 9, Phase 2/3 1, Phase 2 3) 2017: 24 trials (Observational 4, Not applicable 9, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 6, Phase 1/2 1) 2018: 21 trials (Observational 12, Not applicable 4, Phase 4 2, Phase 3 2, Phase 1 1) 2019: 21 trials (Observational 7, Not applicable 5, Phase 4 3, Phase 3 3, Phase 2 1, Phase 1 2) 2020: 24 trials (Observational 12, Not applicable 6, Phase 3 4, Phase 2/3 1, Phase 2 1) 2021: 26 trials (Observational 11, Not applicable 7, Phase 4 2, Phase 2/3 1, Phase 2 3, Phase 1 2) 2022: 23 trials (Observational 13, Not applicable 6, Phase 4 2, Phase 2 1, Phase 1 1) 2023: 32 trials (Observational 16, Not applicable 8, Phase 4 1, Phase 3 5, Phase 2 1, Phase 1 1) 2024: 24 trials (Observational 11, Not applicable 9, Phase 4 1, Phase 2 3) 2025: 27 trials (Observational 12, Not applicable 9, Phase 4 2, Phase 3 2, Phase 2 1, Phase 1/2 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 27
2025 27
2024 24
2023 32
2022 23
2021 26
2020 24
2019 21
2018 21
2017 24

Forecast of the full-year count, planned starts included, not rows of this table: about 32 trials starting in 2026 and about 26 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 31 months from start to primary completion across 21 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 323 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Spondylitis, Ankylosing trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 16
Phase 1/2 5
Phase 2 43
Phase 2/3 9
Phase 3 73
Phase 4 58
Not applicable 94
Observational 216
Expanded access 1

How many Spondylitis, Ankylosing trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 27
Recruiting 48
Enrolling by invitation 2
Active, not recruiting 13
Completed 302

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Spondylitis, Ankylosing trials? (10)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Novartis Pharmaceuticals 19
Pfizer 19
AbbVie 15
Wyeth is now a wholly owned subsidiary of Pfizer 14
Merck Sharp & Dohme LLC 13

Which drugs are being tested for Spondylitis, Ankylosing? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
INFLIXIMAB 30
Sulfasalazine 6
Certolizumab 5
Filgotinib 4

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
1=Etanercept 36
Adalimumab-US 32
Secukinmab 21
SC golimumab 15
HD- Methotrexate (MTX) 7

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Spondylitis, Ankylosing trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 119 31
Dyspnoea 82 11
Osteoarthritis 69 23
Pyrexia 55 13
Ankylosing spondylitis 50 19

Which publications cover Spondylitis, Ankylosing? (595)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages